I am an environmental toxicologist and the AstraZeneca global lead for the development of innovative science to support future environmental risk assessments and secure the environmental safety (eco-toxicology) of pharmaceuticals; fundamental for sustainability.
As a comparative physiologist and expert fish biologist, 我领导了行动模式驱动的调查,提供了对人类药物如何在动物身上起作用的机制理解,以便更好地预测野生动物可能面临的风险.
我热衷于推动水生安全测试范式远离动物研究的研究. 我通过研究新的替代方法来做到这一点,例如使用细胞在培养中构建3D类器官组织. At AstraZeneca I am the global lead for the 3Rs (reduction, 我很自豪能够主持享有盛誉的澳门在线赌城娱乐奖,帮助分享这些团队的创新成果.
我很荣幸能与我所在领域的一些顶尖学者和意见领袖一起工作,并发表了65多篇科学论文. 我广泛支持早期职业科学家,我是埃克塞特大学生命与环境科学学院的荣誉副教授. 2021年,我加入了独立的英国政府有害物质咨询委员会, 利用新方法方面的专业知识支持未来的化学品评估.
通过与学术界一些最优秀的科学家和领导者合作, 我正在努力寻找更好的方法来预测化学品对环境的潜在影响.
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Hon Associate Professor, University of Exeter.
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Hazardous Substances Advisory Committee (HSAC)
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AstraZeneca Council for Science and Animal Welfare
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CURRENT ROLE
2021
2021
2020
Featured publications
超越病人:帮助预测药物在环境中的命运和影响的先进技术.
Chapter 11 by Owen & Snape in: The Era of Artificial Intelligence, Machine Learning, and Data Science in the Pharmaceutical Industry. Academic Press, 2021, Pages 217-235, ISBN 9780128200452.
http://www.sciencedirect.com/science/article/pii/B978012820045200012X
环境中非甾体抗炎药(NSAIDs)混合物对鱼类构成风险的药理学预测.
Marmon et al., 2021 Environment International 146, 106222
http://www.sciencedirect.com/science/article/pii/S0160412020321772
近期展望:弥合人类健康与环境的鸿沟. 迈向了解跨物种化学安全评估机制的综合策略.
Rivetti et al., 2020 Toxicology in Vitro 62, 104692
http://www.sciencedirect.com/science/article/abs/pii/S0887233319304722
测试斑马鱼的翻译能力:对心血管药物反应的跨物种分析.
Margiotta-Casaluci et al., 2019 Frontiers in pharmacology 10, 893
http://www.frontiersin.org/articles/10.3389/fphar.2019.00893/full
超越病人的药理学——人用药物的环境风险.
Gunnarsson et al., 2019 Environment International 129, 320-332
http://www.sciencedirect.com/science/article/pii/S0160412019309493
利用机器学习预测鱼类和无脊椎动物的生物浓度因子.
Miller et al., 2019 Science of The Total Environment 648, 80-89
http://www.sciencedirect.com/science/article/pii/S0048969718330869
环境毒理学的机器学习:对整合和创新的呼唤.
Miller et al., 2018 Environmental science & technology 52 (22), 12953
A review of the pharmaceutical exposome in aquatic fauna.
Miller et al., 2018 Environmental Pollution 239, 129-146
http://www.sciencedirect.com/science/article/pii/S0269749117352375
用分子描述符模拟鱼原代鳃细胞培养上皮的药物摄取.
Chang et al., 2018 Environmental science & technology 53 (3), 1576-1584
ECOdrug:一个连接药物和跨物种目标保护的数据库.
Verbruggen et al., 2018 Nucleic acids research 46 (D1), D930-D936